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The magnesium peroxide is a source both of amounts indicated. One n the amounts indicated. One suitable source of the magnesium peroxide is Hummel Croton Inc. As mentioned, the colostrum product of the above examples may be taken orally as a colostrum supplement with all of the attendant benefits, or it may be admixed with compatible minerals, vitamins or enzymes, and the like, or it may be used as the outer shell of a multilayered pill or capsule to separate, temporarily, possible incompatible materials.

In accordance with this preferred form of the present invention, the colostrum materials are used to form the outer shell of a pill or tablet whose inner core may be any one of a variety of mixtures depending upon the overall intended function of the pill or tablet. Many of the various core types have already been mentioned.

In operation, the outer shell is dissolved first upon consumption of the pill and metabolized by the body followed by dissolution and assimilation of the components of the inner core.

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The following are several examples of a variety of composite pills and tablets in accordance with this aspect of the invention. The above materials form the outer shell while the inner core includes the following materials in the amounts indicated.

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The above example is an immune system tablet and contains ingredients to fight off free-radicals which are believed to cause many diseases as well as being at the heart of the aging process. The vitamin and mineral supplement of the preceding example is intended to enhance overall wellness and provide to the body the essential and trace minerals needed to ward off diseases and to maintain balanced health.

The following is an example of a cholesterol fighting supplement which includes a combination of omega fatty acids. Omega fatty acids cannot be synthesized by the body and cholesterol is believed to be minimized in the blood stream when adequate supplies of Omega acids are present in the blood stream. Many raw fruits, vegetables and herbs contain metabolic enhancing components known as phytochemicals. The phytochemicals work with vitamins, minerals, proteins and fatty acids and enzymes to enhance metabolic function and cellular activity.

The following is an example of a body conditioner and cleansing supplement in accordance with this invention. Magnesium in combination with oxygen deodorizes the lower digestive system and helps the body fight off pathogenic bacteria, parasites, yeasts, and the like, that may reside in the digestive tract. The remaining ingredients help boost the immune system as the body goes through the cleansing cycle.

It is apparent from the above detailed description that processed bovine colostrum and a stable source of oxygen in the form of magnesium peroxide, along with other materials such as vitamin C and magnesium succinate and the bioflavonoids provide a powerful supplement for the human body. The colostrum and vitamin C boost the immune system's ability to ward off disease, while magnesium provides the body cells with a key ingredient for cellular metabolism. The bioflavonoids are present to facilitate the utilization of vitamin C while the magnesium succinate is used to allow the utilization of magnesium by the body.

With these basic qualities of the principal ingredients of the basic composition, as described, a wide variety of other materials may be added in various amounts, known in the art, to provide added supplemental benefits. The procedure for making the core and the outer shell, where a shell and core structure are used are well known in the art, as are the procedures for forming pills, capsules or tablets.

The colostrum group of ingredients may be used to isolate added components by forming an outer shell that separates those components that are incompatible with the components of the shell material by forming pills or tablets having an inner core and outer shell. It is also the case that such separation. Accordingly, it is intended that the scope of this patent be limited only by the scope of the appended claims and equivalents thereof.

Effective date : A consumable supplement contains a colostrum component composed of processed bovine colostrum, magnesium peroxide as a source of active oxygen, a vitamin such as vitamin C, magnesium succinate and a bioflavonoid. This colostrum component can be taken separately or admixed with other minerals, vitamins and the like. In one form, the colostrum component is used as an outer shell for a composite pill, tablet or capsule which includes an inner core containing one or more vitamins, minerals, enzymes or omega acids in the event that the components of the inner core are incompatible with one or more materials of the colostrum component.

In this way, a wide variety of supplements may be provided offering the advantages of colostrum and active oxygen and the advantages of other materials which may be taken as a single pill or capsule. Various supplements and formulations are described as well as various amounts of the varius components of the supplement.

FIELD OF THE INVENTION This invention relates to consumable products containing colostrum, more particularly to improved vitamin and mineral supplements and related products which contain activated oxygen and which include colostrum, both in solid form, and which provide many advantages as well as beneficial effects as dietary supplements, improved metabolic function and rapid adsorption into the body. The following example is for a vitamin and mineral supplement. The following example is of a product which contains a combination of enzymes.

What is claimed is: 1. An ingestable supplement as set forth in claim 1 including an inner core and wherein the colostrum product forms an outer shell encapsulating the core. An ingestable supplement as set forth in claim 1 wherein said mineral peroxide is magnesium peroxide and wherein said succinate is magnesium succinate.

An ingestable supplement in claim 2 wherein said core includes Omega acids. An ingestable supplement in claim 2 wherein said core includes at least one vitamin. An ingestable supplement in claim 2 wherein said core includes at least two enzymes. An ingestable supplement in claim 2 wherein said core includes at least two herbs.

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An ingestable supplement in claim 2 wherein said core includes at least two minerals. An ingestable supplement as set forth in claim 2 wherein said core includes natural fiber. USA en. Composition comprising plant extracts, vitamins, organic selenium, lecithin, glycerin, chlorophyll and homeopathic agents, useful for nourishing the skin, nails and hair and reducing hair loss.

USB1 en. Method of using immunoglobulin and fiber-containing compositions for human health. USB2 en. Method for improvement and modulation of humane immune response through supplementation of colostrum. Method for increasing calcium absorption and bone mineral density through the supplementation of bovine colostrum.

Dairy-derived anticholesterol immunoglobulin to lower dietary cholesterol in humans. Method of enhancing intestinal pinocytosis of immunoglobulins in postnatal domestic mammals. Dietary supplements in beverages or other forms, and methods of use and production. WOA1 en. Compositions and methods for treatment in broad-spectrum, undifferentiated or mixed clinical applications. Colostrum fraction, a process of preparing it and its use as a supplement in cell culture media. Method of reducing blood cholesterol and triglyceride levels using combinations of vasoprotective agent. Method of treating vascular injuries induced by an excess of plasma lipids using combinations of vasoprotective agents.

Method for enhancing physical performance or immune system recovery from intense physical excercise with quercetin-containing compositions. EPA1 en. Compositions for human and animal consumption containing reduced folates and methods for making and using same.

EST3 en.

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Aggett et al. RUC2 en. FIC en. Foerfarande Foer framstaellning of a fettkomposition and an foedoprodukt, som aer laemplig Foer smaobarn. USA1 en. Universal protein formulation meeting multiple dietary needs for optimal health and enhancing the human immune system. For example, collaboration could focus on comparing, with an epidemiological objective, Bartonella strains sampled from humans and different animal species. In certain fields, research carried out in human biology and animal health use similar tools, and even the same models, to address research questions.

When this is the case, notably in the framework of the study of zoonotic pathogens, the only difference lies in the nature of the questions explored. In certain circumstances, the convergence continues up to point where the biomedical and animal health teams share the same questions, and then no evident distinguishing feature remains. The development of projects initially focused on animal health progressively may lead the teams involved to pose questions that are increasingly focussed on models shared with human biology. As an illustration, we may cite fundamental research approaches to the molecular mechanisms of the invasion of cells targeted by the influenza virus, or the biological origin of prions and the determinants of the species barrier modulating their transmission capacity.

In such cases, it is easy to imagine that the same research could be conducted in research laboratories unrelated to animal health. However, an animal health perspective offers certain advantages, notably expertise for extensive experimental research in a confinement area, and special links maintained through collaborations with other scientists working notably in the fields of pathogenesis and animal genetics. The discussion presented here was conducted in relation to human biology research work. A parallel approach could be envisioned in relation to work carried out on plant health.

Such an analysis may elicit a certain community of tools and methods with animal health, an advantage of comparative biology, but apparently few shared issues at stake for the pathogens of interest. Mice often prove to be an inadequate model in physiopathological, prophylactic, and therapeutic studies for humans.

This is due to the reduced size of the species, physiological considerations, and the absence of a natural corresponding pathology. With regard to the latter point, it often is necessary to infect a mouse with the human pathogen agent, and thereby create an artificial model without pertinent symptoms. In certain situations, domestic species prove to be better study models for human-oriented research. Domestic species can be infected by viruses that have co-evolved with their host.

These diseases present similarities in molecular and physiopathologic mechanisms to human disorders without being zoonotic. Pigs infected by an influenza virus that has adapted to pigs thus suffer an influenza syndrome resembling that found in humans infected with a human influenza virus. Young calves infected by a respiratory syncytial virus distinct from the human virus develop a broncho-pulmonary pathology close to that of a child.

These animal disorders thus allow the development of therapeutic, vaccination, and diagnostic strategies that can be adapted or extrapolated to humans. Furthermore, through evolutionary convergence, certain domestic species present more functional similarities to humans than mice: for example, sheep for respiratory pathology immunologic study of asthma treatment , and pigs for skin structure study of transcutaneous therapy or vaccination , cardio-vascular diseases, and the development of spontaneous melanoma where the progression of tumors resembles that observed in humans.

Lastly, domestic animals, due to their large size, allow immune functions to be studied in an original manner that would not be possible with mice. It thus is possible to catheterize lymphatic vessels in pigs, cows, and sheep to study baseline migrant leukocyte populations directly in the lymph during an infection or vaccination, enabling certain immune response features to be monitored in real time. For these different reasons, in-depth knowledge of domestic animal physiopathologies and the existence of high performance animal experimentation platforms are useful for biomedical research.

Overall, the diversity of models animal species studied, the foundation of comparative biology, is important to produce general knowledge that can have diverse applications, notably in human biology. Compared to research on pathogens affecting public health, it is notoriously difficult to find funding for research dedicated to animal health that is focussed on non-zoonotic pathogens or to publish the results in high quality scientific journals.

These difficulties seem to be inversely proportional to the genericity of the knowledge produced and to its potential biomedical contribution. For example, in a call for proposals on infectious disease research, an excellent project on a non-zoonotic pathogen will systematically be eclipsed by a project addressing a topic such as hemorrhagic fevers due to the evaluators' perception of the stakes involved.

Similarily, numerous human health and scientific journals that have a high impact factor due to the larger size of the scientific community involved in human biology compared to animal health, rarely accept an article on non-zoonotic agents that effectively fall outside their domain. This state of affairs is extremely important to take into consideration given the current imperative to obtain credit to finance research and the use of the "impact factor" criteria in the scientific evaluation of research teams.

This point is even more critical as the apparent proximity of animal health and human biology sectors nevertheless does not render their objectives equivalent. An overly hasty approach to the question by evaluators who are ill-informed or insufficiently aware of the issues involved will lead them to apply criteria and indicators to animal health research that are appropriated from human biology and which are completely unsuitable, and indeed unfair, in the field of animal health. Research units that address both zoonotic and non-zoonotic pathogens face a delicate situation.

Teams within the same unit are not in the same boat with regard to seeking funding and publication levels. What emerges from this analysis is that, when research of equivalent scientific quality are considered together, work on non-zoonotic diseases are financed less easily, and are published in journals with a lower impact factor, than work on zoonotic animal diseases.

In a similar fashion, research on animal diseases are financed and published less easily than human biomedical research. It thus is absolutely necessary to act far upstream of national and international research programmes by ensuring that calls for research proposals specifically mention the issues at stake in animal health on one hand, and that research organizations for their part officially adopt a policy to recognize the stakes and scientific outputs that are specifically linked to animal health.

A parallel may be drawn between the domain of research and that of disease surveillance and control. OIE officials call attention to a school of thought circulating at the international level that suggests economies of scale would be possible if veterinary medicine services were regrouped with human health facilities in each country. Along the same lines, public services such as disease surveillance are perceived to be expendable variables that may be played with to cut costs in debt-ridden countries.

In the same spirit, this school of thought also advocates that only animal diseases posing risks to humans should be considered important due to their zoonotic character. In such a logic of cost-cutting and the regrouping of animal and human health spheres, financial trade-offs naturally would favour human health priorities at the expense of veterinary services.

The OIE's strategy is to take the opposing view which holds that prevention costs less than resolving crises, and that quality prevention is based on national animal health systems that can ensure appropriate surveillance, early detection, transparency, and rapid response to animal disease outbreaks and on a durable network of veterinary services endowed with a specific budget. Thus in , the OIE reiterated its affirmation that veterinary services were a global public good [ 25 ]. The disastrous consequences of cutbacks in public services, and the efficacy of the preventative and global approach taken by the OIE, is leading progressively to a swing of opinion in favour of this approach.

This change is visible, for example, in the international documents debated during successive forums on the control of avian influenza [ 26 ]. Most pharmaceutical companies have subsidiaries dedicated to animal health, which is related to the fact that economic scales between animal and human health cannot be compared; as an example, sales of a human vaccine may be 20 to 50 times higher than those of a veterinary vaccine.

If a choice must be made between two very different vaccine projects, even if each is a priori profitable, the human vaccine automatically will be chosen over the veterinary vaccine. In the same manner, shared services will be put at the disposal of the human vaccine project given the higher economic stakes involved.

Lastly, it also is more difficult to find public funding, and thus complementary private funding, for the development of vaccines against non-zoonotic pathogens than for human vaccines. A fusion between human and animal activities would translate into the disappearance of the animal sector, or into animal models being developed only when they have a direct interest for humans. In contrast, what is shared by animal and human vaccines is an ensemble of vaccine production technology, innovations in this field and preceding research on pathogen families, cytology, certain features of immunology, all knowledge that deserves to be shared between human and animal health in the form of cooperation.

As mentioned by the Director of the OIE in an editorial [ 27 ], the "One World, One Health" approach is indispensable in the sense that " the only way to prevent all these new hazards zoonotics is to adapt the existing systems of health governance at world, regional and national levels in a harmonised and coordinated manner ", but " the concept "One World, One Health" should not serve as a pretext for dangerous initiatives like trying to achieve economies of scale based on purely theoretical notions worthy of a sorcerer's apprentice, such as trying to merge the Veterinary Services and the Public Health Services ".

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Taking this perspective, it effectively is out of the question to merge services because each must assume its functions with the resources dedicated to it and the approaches suited to its particular mission; however, it is necessary to develop collaboration, cooperation, and synergies [ 28 ].

Different discussions are underway to define ways to implement this cooperation between organisations. The present discussion, the opinion of experts, and a critical reading of the literature has led to the following observations. International bodies WHO, FAO, OIE affirm that, over and above the threat of diseases that can be transmitted to humans zoonotic diseases , the challenges facing the field of animal health are considerable. They concern food security, economics, agriculture and associated economic activities in both industrialized and developing countries.

The challenges facing animal health, beyond those posed by zoonotic diseases, overlap with those of public health and the environment, notably regarding the use of xenobiotics and the development of antibiotic resistance. The distinguishing features of animal health research are methodological and scientific in nature. They notably pertain to special biological features of domestic species and to the interaction between humans in their practice of livestock husbandry and animals in their biology and evolution.

Animal biology generally does not pursue the same scientific questions as human biology, even when the same pathogens are being studied, and the discipline is rooted in a very specific agricultural and economic context. For animal health stakeholders, whether from the perspective of research or development, finding an optimal balance between the economic profitability of a farm, animal welfare, the maintenance of animal health and the quality of products of animal origin involves close collaboration between animal husbandry sciences and the agricultural profession.

Knowledge produced by comparative biology is fed by research conducted on animal species. For example, animal models are a source of generic knowledge due to their special evolutionary features and, in certain cases, their functional similarities with humans. The diversity of the model species studied and the control of particular infectious diseases contribute greatly to the production of knowledge about living organisms. These observations present a strong case in favor of taking into account the uniqueness of animal health research, in terms of its organization, evaluation, and funding, compared to biomedical research.

If this is not done, strictly biomedical priorities will lead to the elimination, sooner or later, of quality research on non-zoonotic animal diseases. A special "treatment" of this research thus is necessary with regard to the issues at stake; specially designed calls for proposals should be dedicated to the field, the field's journal corpus should be recognized as being different from that of biomedical research, and the research should be evaluated in the light of this specific corpus.

The "One Health" approach is important insofar as it argues that the management of health requires reinforced coordination between human and animal components and, in the same manner, in-depth collaboration between biomedical and animal health research. The organization of such collaboration can only reinforce the capacity of both groups to produce relevant science, and to realize the potential of research efforts and more global approaches integrating human and animal components in federated projects.

In terms of research, this collaboration may assume different forms and take place at different levels, ranging from cooperation between teams up to the organization of research and its funding. The questions explored in animal health and human biology regarding the same zoonotic pathogen frequently are complementary. They allow scientific collaborations to be built that can respond to more general questions, and notably to address the complexity of the biological systems of certain diseases.

Another form of collaboration is the establishment of calls for joint public health and animal health proposals for research on pathogens whose study and control require combined research approaches. This has been the case for research on transmissible spongiform encephalopathies, with joint animal-human calls for projects and pluridisciplinary projects in the United Kingdom, Netherlands, Germany, France and the European Union.

At a more general level, comparative biology represents a precious source of knowledge. TP and CD designed the work and defined the working group. CD chaired the discussions and coordinated the paper. All authors read and approved the final manuscript. National Center for Biotechnology Information , U. Journal List Vet Res v. Vet Res. Published online Aug Author information Article notes Copyright and License information Disclaimer. Corresponding author. Christian Ducrot: rf.

Received Jun 8; Accepted Aug This article has been cited by other articles in PMC. Abstract In the rapidly changing context of research on animal health, INRA launched a collective discussion on the challenges facing the field, its distinguishing features, and synergies with biomedical research.

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Table of contents 1. Introduction 2. Issues and special features of animal health research 2. Animal health and veterinary public health 2. Issues at stake in animal health 2. Importance of diseases, prioritization of issues at stake 2. Special features of diseases according to the types of animals 2. Prioritization of issues at stake 2. Issues at stake in animal health research 3. Special features of animal health research 3.


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Distinguishing features of the objectives, methods, and biological models 3. Special features of scientific questioning 3. Generic and methodological areas of convergence with human health 4. Relationships between animal health and human health research 4. Domestic animal models for human targeted research 4. Funding and evaluation of research 4. Parallels between research, surveillance of diseases and the pharmaceutical industry 4. Surveillance and control of diseases 4. Pharmaceutical industry 4.

The "One world, One Health" approach 5. Conclusion Competing interests Authors' contributions Acknowledgements References. Introduction Understanding of animal health research, and the expectations of donors and research organizations, is changing. Animal health and veterinary public health In animals, health may be defined as the absence of disease or the normal functioning of an organism and normal behaviour based on the observation of a certain number of individuals that determine the standard and thus health [ 1 ].

Special features of diseases according to the types of animals For production animals, infectious and parasitic diseases predominate, even if metabolic and degenerative disorders naturally exist that most frequently are related to an insufficient control of production systems. Prioritization of issues at stake It is difficult to arrange the different challenges presented by animal diseases and their control into an order of priority.

Issues at stake in animal health research Precise light was thrown on the subject by a bibliometric study covering the period conducted under the European Era-Net EMIDA programme Emerging Infectious Diseases of Animals [ 14 ] which focused on infectious and parasitic diseases of production animals. Open in a separate window. Figure 1. Special features of animal health research Animal health research is distinguished by particular objectives, methods, biological models and scientific questions.

Distinguishing features of the objectives, methods, and biological models First of all, livestock farming is an economic activity whose end goal is to generate revenue. Special features of scientific questioning In addition to the aspects discussed in the preceding sections, one of the main distinguishing features of animal health research are the scientific questions pursued, which are posed from the perspective of animal, and not human, health. Generic and methodological areas of convergence with human health In certain fields, research carried out in human biology and animal health use similar tools, and even the same models, to address research questions.

Domestic animal models for human targeted research Mice often prove to be an inadequate model in physiopathological, prophylactic, and therapeutic studies for humans. Funding and evaluation of research Compared to research on pathogens affecting public health, it is notoriously difficult to find funding for research dedicated to animal health that is focussed on non-zoonotic pathogens or to publish the results in high quality scientific journals. Surveillance and control of diseases A parallel may be drawn between the domain of research and that of disease surveillance and control.


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Pharmaceutic industry Most pharmaceutical companies have subsidiaries dedicated to animal health, which is related to the fact that economic scales between animal and human health cannot be compared; as an example, sales of a human vaccine may be 20 to 50 times higher than those of a veterinary vaccine.

The "One World, One Health" approach As mentioned by the Director of the OIE in an editorial [ 27 ], the "One World, One Health" approach is indispensable in the sense that " the only way to prevent all these new hazards zoonotics is to adapt the existing systems of health governance at world, regional and national levels in a harmonised and coordinated manner ", but " the concept "One World, One Health" should not serve as a pretext for dangerous initiatives like trying to achieve economies of scale based on purely theoretical notions worthy of a sorcerer's apprentice, such as trying to merge the Veterinary Services and the Public Health Services ".

Conclusion The present discussion, the opinion of experts, and a critical reading of the literature has led to the following observations. Competing interests The authors declare that they have no competing interests. Animal health: a layman's guide to disease control. Definition of health and disease in textbooks of veterinarian medicine. Animal production in Europe: The way forward in a changing world. Definition of criteria for overall assessment of animal welfare. Anim Welf. Livestock production: recent trends, future prospects. A compartmentalised model for the estimation of the cost of coccidiosis to the world's chicken production industry.

Int J Parasitol. Production effects related to mastitis and mastitis economics in dairy cattle herds. Economic costs of the foot and mouth disease outbreak in the United Kingdom in Rev Sci Tech. World mapping of research institutions, topics and collaboration in the field of infectious diseases of animals; a bibliometric analysis using publication records extracted from the Web of Science Report, 47 pp,